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BIND project

Duchenne Data Foundation   →  EU Projects   →  BIND project

PROJECT OVERVIEW

Learning and behavioural issues in DMD/BMD

This EU-funded project connecting 19 partners aims to address learning and behavioral issues in Duchenne Muscular Dystrophy and Becker Muscular Dystrophy. This aspect was already recognized in 1861, when Duchenne de Boulogne first described the neuromuscular condition.

Brain involvement received less attention

However, in the last few decades, most of the efforts have focused on improving outcomes related to muscle weakness. Brain involvement received less attention. The BIND project is the first project of this scale to improve characterization of brain involvement in DMD and BMD, and analyze learning and behavioral issues.

Our Role

DDF is responsible for:

  1. The collection, curation, and integration of non- and clinical data.
  2. Providing a secure repository under Data FAIR Principles and GDPR regulations for all the data produced during the project;
  3. Supporting data related activities to be compliant with the predefined Ethics Requirements;
  4. Contributing to the creation of a data management plan following the H2020 guidelines. The plan addresses the FAIRification procedure of data, following the principles of Open Science, the accessibility, verification, re-use, curation and preservation of data;
  5. Participating in the communication and dissemination activities;
  6. Training of BIND partners on FAIR principles and data FAIRification processes.
VISIT BIND WEBSITE
Goal 1

PLACE & FUNCTION

Localising the isoforms that the Duchenne & Becker muscular dystrophy locus produces in the brain and their function
Goal 2

Understanding

Improve understanding of postnatal brain restoration of different dystrophin isoforms using preclinical models.
Goal 3

Definition

Defining the spectrum of brain comorbidities in DMD and BMD individuals, and how to best assess them.
Goal 4

Assessment

Creating optimal and uniform outcome measures to assess brain comorbidities in Duchenne and Becker MD.

Benefit the broader neuromuscular field

As well as being of great importance for the Duchenne and Becker community, this project might also benefit the broader neuromuscular and neurodevelopmental field. Brain comorbidity neurobiology is poorly understood, and standards of care not widely disseminated and implemented. This four-year project describing the contribution of a specific protein (dystrophin) to brain function could be of crucial value for the broader neurobiology field, including autistic spectrum disorders.

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This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 847826.

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