Learning and behavioural issues in DMD/BMD

This EU-funded project connecting 19 partners aims to address a crucial aspect of Duchenne Muscular Dystrophy and Becker Muscular Dystrophy that was already recognised in 1861, when Duchenne de Boulogne first described the neuromuscular condition.

Brain involvement received less attention

However, in the last few decades, most of the efforts have focused on improving outcomes related to muscle weakness, whilst brain involvement has received less attention. The BIND project is the first project of this scale to improve characterisation of brain involvement in DMD and BMD, a previously overlooked field.

Goal 1


Localising the isoforms that the Duchenne & Becker muscular dystrophy locus produces in the brain and their function
Goal 2


Improve understanding of postnatal brain restoration of different dystrophin isoforms using preclinical models.
Goal 3


Defining the spectrum of brain comorbidities in DMD and BMD individuals, and how to best assess them.
Goal 4


Creating optimal and uniform outcome measures to assess brain comorbidities in Duchenne and Becker MD.

Benefit the broader neuromuscular field

As well as being of great importance for the Duchenne and Becker community, this project might also benefit the broader neuromuscular and neurodevelopmental field. Brain comorbidity neurobiology is poorly understood, and standards of care not widely disseminated and implemented. This four-year project describing the contribution of a specific protein (dystrophin) to brain function could be of crucial value for the broader neurobiology field, including autistic spectrum disorders.


This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 847826.